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A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma

Houli Zhao, Yiyun Wang, Elaine Tan Su Yin, Kui Zhao, Yongxian Hu, He Huang

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 711-725 doi: 10.1007/s11684-020-0808-3

Abstract: Nonetheless, the CAR-T therapy was usually associated with potentially lethal adverse effects, such as the cytokinerelease syndrome and the neurotoxicity.

Keywords： chimeric antigen receptor T (CAR-T) cell     lymphoma     cytokine release syndrome (CRS)     immune effector cell-associatedneurotoxicity syndrome (ICANS)    

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Management of cytokine release syndrome related to CAR-T cell therapy

Hongli Chen, Fangxia Wang, Pengyu Zhang, Yilin Zhang, Yinxia Chen, Xiaohu Fan, Xingmei Cao, Jie Liu, Yun Yang, Baiyan Wang, Bo Lei, Liufang Gu, Ju Bai, Lili Wei, Ruili Zhang, Qiuchuan Zhuang, Wanggang Zhang, Wanhong Zhao, Aili He

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 610-617 doi: 10.1007/s11684-019-0714-8

Abstract: Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threateningThis syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immunerecurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRSpatients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRSThe effective management of the toxicities associated with CRS will bring additional survival opportunities

Keywords： chimeric antigen receptor T cell     cytokine release syndrome     tocilizumab    

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Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma in Chinese patients

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 285-294 doi: 10.1007/s11684-021-0843-8

Abstract: The incidence of cytokine release syndrome in all grades and grade≥3 was 90% and 0, respectively, which

Keywords： CAR-T cell therapy     refractory diffuse large B-cell lymphoma     cytokine release syndrome     dose-limiting    

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Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 139-145 doi: 10.1007/s11684-015-0377-z

Abstract: In summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance

Keywords： inflammation     obesity     cytokine     energy expenditure     insulin resistance    

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Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

Frontiers of Medicine doi: 10.1007/s11684-023-1044-4

Abstract: Several patients have developed pneumonia, which can deteriorate into acute respiratory distress syndromeThe primary etiology may be attributed to cytokine storm, which is triggered by the excessive releasedetected in several highly pathogenic coronavirus-infected diseases, such as severe acute respiratory syndromein 2002, the Middle East respiratory syndrome in 2012, and COVID-19, the IL-6 pathway has emerged asThus, we review the history of cytokine storm and the process of targeting IL-6 signaling to elucidate

Keywords： SARS-CoV-2     COVID-19     cytokine storm     interleukin-6     tocilizumab    

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Inflammation and liver tumorigenesis

Beicheng Sun, Michael Karin

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 242-254 doi: 10.1007/s11684-013-0256-4

Abstract:

Inflammation has been considered as one of the hallmarks of cancer, and chronic hepatitis is a major cause of liver cancer. This review will focus on the pathogenic role of inflammation in hepatocarcinogenesis and will discuss recent advances in understanding the chronic hepatitis-liver cancer link based on hot spots in liver cancer research, including cellular interaction, cytokines, microRNA and stem cells. All of these mechanisms should be taken into consideration because they are crucial for the development of more efficacious therapeutic strategies for preventing and treating human chronic hepatitis and hepatocellular carcinoma.

Keywords： hepatocellular carcinoma     hepatitis     cytokine     stem cell     miRNA    

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High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells

Synat Kang, Yanyan Li, Yifeng Bao, Yi Li

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 69-82 doi: 10.1007/s11684-018-0677-1

Abstract:

Cytokine-activated T cells (CATs) can be easily expanded and are widely applied to cancer immunotherapy

Keywords： cytokine-activated T cells     high-affinity T cell receptor     cancer immunotherapy     TCR-CAT    

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Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic

Vaibhav Mundra, Ram I. Mahato

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 387-404 doi: 10.1007/s11705-014-1457-3

Abstract: Viruses exploit intracellular cues to release the genome to cytosol.

Keywords： nanocarrier     cellular uptake     endosomal release     nucleic acid drug    

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Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 651-658 doi: 10.1007/s11684-021-0859-0

Abstract: To present the clinical characteristics and the misdiagnosis rate of acute coronary syndrome manifestedcomplaint of throat discomfort, absence of chest pain at onset, and an ultimate diagnosis of acute coronary syndromedyspnea, perspiring, and exertional throat symptoms were significantly associated with acute coronary syndromeThroat discomfort can be the principal manifestation of acute coronary syndrome.throat symptoms, chest tightness, perspiring, and dyspnea were important indicators of acute coronary syndrome

Keywords： acute coronary syndrome (ACS)     throat discomfort (TD)     throat pain     cardiology departments     non-cardiologic    

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Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 73-83 doi: 10.15302/J-FASE-2015044

Abstract: Suppressor of cytokine signaling 1 (SOCS1) protein can inhibit the signal transduction triggered by someTaken together, these data suggest that both cSOCS1a and cSOCS1b may function as negative regulators of cytokine

Keywords： chicken     SOCS1a     SOCS1b     growth hormone     prolactin    

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Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2,   Pages 225-232 doi: 10.1007/s11705-014-1429-7

Abstract: Here we review several common semi-solid polymers currently used in the controlled release formulations

Keywords： controlled release     drug delivery     semi-solids     polymer     excipient    

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Aneurysmal dilatation of the aortic sinuses of Valsalva — beyond Marfan syndrome: a single centre experience

Maryanne Caruana,Mary N. Sheppard,Wei Li

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 419-426 doi: 10.1007/s11684-014-0383-6

Abstract: of Valsalva has been most extensively documented in the setting of aortopathies, particularly Marfan syndromereview, we carried out a literature search on aneurysmal dilatation of the sinuses of Valsalva in Marfan syndromeIn conclusion, there are differences in management of aortic dilatation in Marfan syndrome and congenital

Keywords： sinus of Valsalva aneurysms     Marfan syndrome     aortic dissection    

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Study on the NOx release rule along the boiler during pulverized coal combustion

JIN Jing, ZHANG Zhongxiao, LI Ruiyang

Frontiers in Energy 2007, Volume 1, Issue 1,   Pages 91-95 doi: 10.1007/s11708-007-0009-7

Abstract: Numerical simulation and experimental study on NO release along the boiler during pulverized coal combustionWith the increase of temperature the NO emission increased and the peak value of NO release moved forwardThe peak value of NO release moved backwards with the increase of coal rank.
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Capacity estimation and preliminary strategy for reducing the release of dioxins in China

YU Gang, ZHANG Qing, HUANG Jun, CAI Zhenxiao, SUI Qian

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 1,   Pages 13-17 doi: 10.1007/s11783-007-0002-8

Abstract: The strategy and action plan for reducing the release of dioxins in China are the most important componentssources for applying the best available technology/best environmental practice (BAT/BEP) to reduce the releaseHow about the capacity for reducing the dioxins release from the key sources?The list of key sources covering about half of the total dioxins release was determined considering fourcorresponding to the scenario that all key sources have been applied BAT/BEP to reduce the dioxins release

Keywords： GIS     difference     capacity     scenario     implementation    

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Synthesis and characterization of biocompatible polyurethanes for controlled release of hydrophobic and

Juichen YANG,Hong CHEN,Yuan YUAN,Debanjan SARKAR,Jie ZHENG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 498-510 doi: 10.1007/s11705-014-1451-9

Abstract: Design of biocompatible and biodegradable polymer systems for sustained and controlled release of bioactiveHere, we designed, synthesized, and characterized four polyurethane carrier systems for controlled releaseBy tuning polyurethane segments, different release profiles of hydrophobic and hydrophilic drugs wereSuch difference in release profiles was attributed to a complex interplay among structure, hydrophobicityan important role of segmental structure of the polyurethane as an engineering tool to control drug release

Keywords： phase structure     degradation     polyurethanes     controlled release     drug delivery    

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Title Author Date Type Operation

A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma

Houli Zhao, Yiyun Wang, Elaine Tan Su Yin, Kui Zhao, Yongxian Hu, He Huang

Journal Article

Management of cytokine release syndrome related to CAR-T cell therapy

Hongli Chen, Fangxia Wang, Pengyu Zhang, Yilin Zhang, Yinxia Chen, Xiaohu Fan, Xingmei Cao, Jie Liu, Yun Yang, Baiyan Wang, Bo Lei, Liufang Gu, Ju Bai, Lili Wei, Ruili Zhang, Qiuchuan Zhuang, Wanggang Zhang, Wanhong Zhao, Aili He

Journal Article

Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma in Chinese patients

Journal Article

Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Journal Article

Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

Journal Article

Inflammation and liver tumorigenesis

Beicheng Sun, Michael Karin

Journal Article

High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells

Synat Kang, Yanyan Li, Yifeng Bao, Yi Li

Journal Article

Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic

Vaibhav Mundra, Ram I. Mahato

Journal Article

Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational

Journal Article

Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Journal Article

Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Journal Article

Aneurysmal dilatation of the aortic sinuses of Valsalva — beyond Marfan syndrome: a single centre experience

Maryanne Caruana,Mary N. Sheppard,Wei Li

Journal Article

Study on the NOx release rule along the boiler during pulverized coal combustion

JIN Jing, ZHANG Zhongxiao, LI Ruiyang

Journal Article

Capacity estimation and preliminary strategy for reducing the release of dioxins in China

YU Gang, ZHANG Qing, HUANG Jun, CAI Zhenxiao, SUI Qian

Journal Article

Synthesis and characterization of biocompatible polyurethanes for controlled release of hydrophobic and

Juichen YANG,Hong CHEN,Yuan YUAN,Debanjan SARKAR,Jie ZHENG

Journal Article